Synthesis and Characterization of Biodegradable hydrogel for Drug Delivery System based on Polyvinyl alcohol

Drug delivery devices are considerable andtheme importance is because of their ability to exertspatiotemporal control over drug release locally at disease site[1]. These controlled systems based on hydrogels that are linear or three-dimention polymers networks formed by chemical or physical crosslinking to retaining large amount of water [2]. Many polymers are used for preparation of hydrogel. Among these polymersPolyvinylalcohol (PVA)is a biodegradable polymer thatcan be used in manybiomedical and pharmaceutical applications, due to its advantages such as nontoxic,non-carcinogenic, and bioadhesive characteristics with the ease of processing[3]. In thepresent study a copolymer based on polyvinylalcohol (PVA) functionalized by Glycidylmethacrylate and acrylamide was synthesized. A macromonomer was prepared with reaction of PVA and GMA in N-methylpyolydone. Then the prepared macromonomer was reacted with acrylamide monomer by free radical polymerization in dimethylacetamid (DMA) as solvent in the presence of benzoilperoxide (BPO) as initiator under Ar atmosphere.After completion of the reaction the product was precipitated and washed with acetone and deionized waterthree times.The synthesized copolymer was characterized with FT-IR,1H NMR,13C NMR, SEM and TGA techniques. This copolymer was investigated as drug delivery system by UV.vis analysis in different factors.