Synthesis and characterization of new imprinted polymer nanocomposites as colon-specific drug delivery vehicles

Molecularly imprinted polymers (MIP) exhibiting high selectivity and Special performance in identifying the target molecule are now seeing a fast growing research. In this paper, we synthesized the new types of nancomposite non-covalent molecularly imprinted polymers (MIPs) and non-imprinted polymers (NIPs) which are used in the field of drug release and by optimizing them can be enhanced effectiveness. The aim of this work was to investigate this new types of nanocomposite as controlled release devices forin biological fluids, especially gastrointestinal. Two types of nanocomposites were synthesized (MIP and NIP) by HF. Through corrosive nature of this type of acid, silica nanoparticles in the polymeric matrix be omitted and amount the holes created for template molecules trapped were increased. The releasing of drug was carried out in cellophane membrane dialysis bags and the in vitro release profiles were established separately in enzyme-free simulated fluids (SGF, pH 1 and SIF, pH 7.4).