Synthesis and characterization of new keto stabilized phosphorus ylide and its complexes with mercury(II) and study their antibacterial properties

Phosphorus ylides are important reagents in organic chemistry, especially in the synthesis of naturally occurring products with biological and pharmacological activities.[1] Since its development the Wittig reaction has remained one of the primary routes utilized in synthetic organic chemistry for the construction of carbon-carbon double bonds.[2] The preparation and characterization of stabilized phosphorus ylides, and metal complexes incorporating in this type of ylides, has attracted much attention in recent years.[3] This work reports on thesynthesis and characterization of a new phosphonium salt and related phosphorus ylide of the type R-COCH=PAr3 and also The reactions of phosphorus ylide (PPh3)3PCHC(O)C5H4CN (Y1) with HgX2 (X = I, Br and Cl) in equimolar ratios using methanol as a solvent. These reactions led to binuclear complexes. The IR, 1H, 13C and 31P NMR technique have been useful for characterization of this complexes. The synthesized ligand and its mercury complexes were screened for their antibacterial activity with using agar disc diffusion method against bacterial species, six Gram negative and positive bacteria. The data showed that have metal complexes much antibacterial activity against bacteria tested.