Synthesis of 1,2,3-triazoles Catalyzed by Cu-Supported SiO2

1,2,3-Triazoles are typical nitrogen-containing heterocyclic molecules that have attracted increasing interest due to their wide range of applications. The 1,2,3-triazole unit is present in several classes of compounds that display different biological activities [1]. Additionally, these components have gained special attention in the drug discovery because several drug molecules contain 1,2,3-triazole group such as Tazobactam, Cephalosporin and Cefatrizine[2].Different methods are available for the synthesis of 1,2,3- triazoles. The most attractive involves the thermal 1,3-dipolar cycloaddition of azides with alkynes, discovered by Huisgen and popularized independently by Sharpless and Meldal [3]. In this method, we have reported synthesis of 1,2,3-triazoles by catalyzed SiO2/2- Aminothiophenol/CuI. The reaction proceeds by mixing the α-bromoketone, sodium azide, alkyne and the catalyzed in aqueous media to afford the desired products in excellent yield. The heterogeneous catalytic system showed highly efficiency, performing the multicomponent Huisgen reaction in a green approach based on recoverability, recyclability and avoidance of wastes