A green approach for one-pot synthesis of cyclic acetals using various aldehydes and diols in the presence of nano--alumina supported BF3 as a new heterogeneous solid acid catalyst

Functional group interconversion (protection/deprotection) is an unavoidable protocol in the synthesis of many designed target molecules such as drugs and multifunctional natural products [1]. In this regard, acetals have widely used as protecting agents in organic synthesis and are an important class of compounds that have found their direct applications in diverse areas in the chemical industry such as perfumes, flavours, pharmaceuticals, solvents and polymer chemistry [2,3]. Due to the toxic nature of many organic solvents, it is suggested to design processes that are rooted in green chemistry.In this work, nano--alumina supported BF3was prepared and characterized by FT-IR, XRD, SEM, TEM and TGA. This new type of solid acid used for synthesis of some cyclicacetals using various aldehydes and diols(Figure 1).The structure of products have been characterized by spectroscopic techniques such as IR and 1HNMR.