A highly efficient and green synthesis of 1,2,3,4-tetrahydropyrimidines under solvent-free conditions

In recent years, the interest in Dihydropyrimidines has increased rapidly because of the structural resemblanceof DHPM with clinically important Hantzsch pyridines [1,2].Pyrimidine derivatives comprise a diverseand interesting group of drugs which are extremely important for their biological activities [3,4]. A mild, simple and efficient procedure for the preparation of 1,2,3,4-tetrahydropyrimidins is described using BSA as an acidic and efficient catalyst under solvent-free conditions. Simple methodologies, easy workup procedure, easy preparation of the catalyst, excellent yields and very short reaction times are among the other advantages of this work. Further, the catalyst can be reused and recovered for several times without significant decrease in its activity.