A multicomponent access to novel Coumarin-3-carboxylic acid derivatives

Isocyanide multicomponent reactions (MCRs) have proved to be extremely versatile entry points to a wide array of novel biologically active scaffolds[1] MCRs, by virtue of this simplicity and the diversity of potential individual components can permit the exquisite positioning of key pharmacophoric moieties in the correct chemical space to enable critical interactions within protein binding sites. Among MCRs,the Ugi and Passerini reactionsare the most popular approaches for the combinatorial chemistry[2,3]. In continuation of our recent research on development of novel multicomponent reactions,in this reaction we wish to report a simple and effient One-Pot four-component reaction of Aniline 1, Isocyanide 2, Aldehyde 3 and Coumarin-3-carboxylic acid 4 to synthesis of novel Coumarin-3-carboxylic acid derivatives 5a-5n.All product were confirmed by 1H NMR,1C NMR spectroscopy , melting point and FT-IR spectroscopy.