چكيده فارسي :
Amides have been synthesized with minimal by-products in a one pot oxidative amidation
of benzyl alcohols with amine hydrochloride salts. This greener amide formation was
completed in the presence of Fe3O4@EDTA@CuCl2 catalyst, base promoter and TBHP as an
oxidant. The catalyst has been characterized by FT-IR, XRD, SEM, VSM, ICP and TG/DTA.
After the completion of the reaction by aid of an external magnet, the catalyst could be
removed from the reaction vessel and reused at least six times without significant loss of its
activity. The measured content of Cu in Fe3O4@EDTA@CuCl2 by inductively coupled
plasma atomic emission spectroscopy (ICP-AES) was 0.4 mmol per gram of catalyst. Amide
functional group has unique characteristics, including invariability, resistant to hydrolysis,
high polarity, diversification of the conformation [1] and acts as prevalent functional group
especially in pharmaceuticals and biologically activecompounds [2]. Amide bond formation
was employed in the synthesis of 66% of drugs developed by pharmaceutical companies such
as GlaxoSmithKline, Astra Zeneca and Pfizer[3]. Therefore, numerous methods for the
synthesis of amides are in the great demand.
