A Novel One-Pot Procedure for the Synthesis of 6-Aminouracils

6-Aminouracils are keyintermediates in the synthesis of xanthineswhich constitutethe basic nucleus of various drugs such as caffeine, 6-mercaptopurine, penciclovir, theophylline, theobromineetc. 6-Aminouracils are also used as startingmaterials for the synthesisof various fused heterocycles with biological importance, suchas pyrido-, pyrazolo- and pyrimidopyrimidines [1]. However, many procedures were reported for the synthesis of 6- aminouracils, the basic and most frequently procedures have beeninvolvingthe condensation of ureas with cyanoacetic acid in the presenceof phosphorous oxychloride or acetic anydride, all these procedures suffer from drawbacks such as use of no recovery of catalysts,lack of simplicity in their experimental procedure. Therefore,developing a synthetic method for a One-Pot synthesis of 6-aminouracils using an environmentally friendlysolvents and conditions is desirable [2].In continues of our previous success on the synthesis of biologically potentially importance heterocycles [3], here, we wish to report a novel and efficient procedure for the preparation of substituted 6-aminouracils2via One-Pot synthesis and oxidation of cyclic diols 1with periodic acid in aqueous media (Figure 1). As shown in the figure1the used oxidant and conditions are in agreement with green aspects of chemistry. The products 2 were characterized based on their IR, Mass and 1H and 13C-NMR Spectra.