چكيده فارسي :
Quinoline ring systems represent a major class of heterocycles in which benzene ring is
fused with pyridine ring. The derivatives of quinoline exhibit diverse biological and
physiological activities such as antimalarial, anti-inflammatory, antitumor, DNA binding
capacity, and antibacterial properties. Recently, quinoline has been employed in the study of
bio-organic and bio-organometallic processes. The quinoline skeleton is often used as a key
intermediate for the design of many pharmacologically important synthetic compounds [1].
The fusion of quinoline to the tetrazole ring is known to increase the biological activity [2].
In this work, we wish to report an efficient One-Pot four component synthesis of 2-amino-
1,4-dihydro pyridine derivatives 4 from the reaction of tetrazolo[1,5-a]quinoline-4-
carbaldehydese1, ethyl-2-cyanozcetat 2, primary amines 3, and di methyl acetylenedi
carboxylate in the presence of DABCO in ethanol. The reaction was completed in 4 hr to
give products in moderate yields.
