Synthesis of 2-amino-4-substituted-1,4-dihydrobenzo[4,5]imidazolo[1,2-a]pyrimidine-3-carbonitriles

Pyrimidinobenzimidazoles possess antimicrobial activity, molluscidal activities, antidiabetic, herbicidal activity, platelet anti-aggregant antiulcer activity, DNA-gyrase inhibitors and anti-inflammatory activities as well as anticancer efficacy.They can play the role of antagonists of the paralyzing action of antidiabetic activity and are important core motifs in a broad range of biologically active compounds that are frequently used in pharmaceutical and drug research, agricultural science, and dye industry [1]. In Thisstudy piperazine-1,4-diium hydrogen sulfate as a new Bronsted acidic catalyst is used for an environment-friendly three-component condensation of 2-aminobenzimidazole, an aldehyde and malononitrile, to afford the corresponding pyrimidine-based annulated di- and triheterocyclic ring systems [2].This method show eco friendly character by elimination of solvent.The other noticeable benefits of this procedure are excellent yields, short reaction times, mild reaction conditions, use of available and inexpensive materials and simple workup procedures.