Synthesis of 4,4´-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol) derivatives using Zirconium Dioxid

Bis(pyrazolyl)methanes (BPMs) such as 4,4´-(arylmethylene)-bis(3-methyl-1-phenyl-1Hpyrazol- 5-ol)s have a broad spectrum of approved biological activities[1], being used as antiinflammatory[ 2], antipyretic [3], gastric secretion stimulatory[4], antidepressant[5], antibacterial[6], and anti-filarial agents. In this work, we have reported the synthesis of 4,4 - (arylmethylene)-bis(3-methyl-1-phenylpyrazol-5-ols) using ZrO2 as reusable catalyst (Figure1). The promising points for the presented methodology are efficiency, generality, high yields, very short reaction times, cleaner reaction profile and simplicity.