Synthesis of biologically active compounds: 7-(4-(1-benzoyl-4-cyano-9-oxo-9H-fluoren-3-yl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

The functional azafluorenones, being the core structural unit in non-naturally and naturally occurring products, serve as ―privileged structures‖ in many biologically active molecules and pharmaceutical substances ]1[. they have also been found in natural alkaloids, such as onychine(I), polyfothine(II), isoursuline(III), which exhibit powerful antimicrobial, DNA damaging, and anticandidal activity as well as anti-malarial effects ]2[. Multi-component domino reactions (MDRs) have been successfully applied to the total synthesis of natural and naturallike products ]3[ becoming one of the key tools that allow the creation of several bonds in a One-Pot manner and offer remarkable advantages like convergence, operational simplicity and facile automation ]4[. we found another new HOAc promoted MDR of arylglyoxal monohydrates with Ciprofloxacinand 1,1-dicyanomethylene-3- indanone yielding polyfunctionalized 2-azafluorenones.This new product was characterized by FT-IR and 1HNMR.