چكيده فارسي :
To date, the development of new methods for the synthesis of heterocyclic compounds has been and remains a hot topic in organic chemistry, due to their importance in biologically active natural products and synthetic materials.The well-known biological properties of benzoxazepines1 and quinazolinones2 prompted us to synthesize molecules in which both nuclei exist. As a part of our ongoing research program on the isocyanide-based MCRs,3 herein, we report the synthesis of oxazepine-quinazolinone bis-heterocyclic scaffolds 4 by an Ugi One-Pot three-component four-center reaction of 2-(2-formylphenoxy)acetic acid 1 as a bifunctional reagent, 2-aminobenzamide 2, and an isocyanide 3. The target compound is obtained without using any catalyst in excellent overall yields. It is worth mentioning that in the course of our reaction, one C-C bond, several C-N bonds, one amide group, a benzoxazepine ring and a quinazolinone ring are newly formed. These new structures broaden the scaffolds that are accessible through Ugi reactions, and may represent interesting pharmacophores.
