An efficient procedure for the synthesis of new silylthioalkyne-substituted 1,2,3-triazole derivatives using LaMnxCu1-xO3 recyclable nanocatalyst in choline chloride/urea deep eutectic solvent

Perovskites as mixed metal oxides have received wide attention, due to their low-cost, appropriate redox properties, stability of mixed oxidation, high thermal stability and high catalytic activity. This material is introduced by the general formula of ABO3, where A is lanthanide or alkaline earth metal ion and B is a transition metal ion. The partial substitution of cations in both places A and B, provided multicomponent oxides with unusual valence in cation sites that usually increased catalytic activity of the perovskite systems [1]. However, few reports have been dedicated to mixed metal oxides in organic synthesis.On the other hand, some new approaches were hired to reduce waste and re-used materials, in order to the both environmental and economic issues. LaMn0.3Cu0.7O3 nanoperovskite oxide was prepared by sol-gel procedure and was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM). The catalyst was used in the 1,3-dipolar cycloaddition of benzyl halide, terminal alkyne and sodium azide. The LaMn0.3Cu0.7O3 as an effective and inexpensive catalyst showed high catalytic activity at room temperature with low catalyst loading, especially in the presence of the choline chloride/urea(ChCl/urea 1:2)deep eutectic solvent [2] as a green medium.The catalyst and the DES could be recycled and reused at least five times without any significant effect on the results of the reaction. In continuous, a series of novel 1,2,3-triazole substitute thioalkynes was synthesized using carbon disulfide and tris(trimethylsilyl)methylithium [3]. These synthetic compounds are valuable intermediates in synthetic chemistry, chemical biology, and material science.