Synthesis of new oximes from octahydroxanthene compoundes based on 1,3-cyclohexanedione

Oximes are important compounds due to the biological and pharmaceutical properties such as antimicrobial [1]and antitumor [2]. In this study, has been designed and synthesized the new series of oxime compounds. The route of synthesis of the mentioned compounds is shown in Figure 1. Reaction of 1,3-cyclohexanedione, aldehydes, and cyanogen bromide lead to the selective formation of octahydro-1H-xanthene-1,8(2H)-diones in moderate to good yields at room temperature under basic condition. Obtained octahydroxantene will be converted to oximes and thiosemicarbazone in the presence or hydroxylamine hydrochloride and thiosemicarbazide, respectively.