Catalytic application of Fe3O4@TiO2@O2PO2(CH2)NHSO3H at the preparation of triarylpyridines via an anomeric based oxidation

Among the pyridine ring system,2,4,6-triarylpyridine derivatives have emerged as potent biologically active heterocyclic compounds due to theirunique applications as therapeutic agents in the field of medicinal chemistry [1,2]. Some of the medical applications of 2,4,6- triarylpyridines are anesthetic, vasodilator, anti-covulsant, antimalarial, antiepileptic and agrochemicals for example pesticidial, fungicidal and herbicidal [3]. Herein, we have developed a green, efficient and powerful protocol for the synthesis of 2,4,6-triarylpyridine derivatives by the reaction of arylaldehydes, acetophenonederivatives and ammonium acetate as nitrogen source. The reaction was performed in the presence of Fe3O4@TiO2@O2PO2(CH2)NHSO3Has a nanomagnetic core-shell catalyst under mild and solvent free conditions (Figure 1). It is worthy to mention that the final step of the mechanistic pathway for the synthesis of target molecules has proceededvia an anomeric based oxidation mechanism.