Synthesis of some new 2-acetamido-N-(2-(cyclohexylamino)-2-oxo-1- phenylethyl)-N,3-diphenylacrylamidederivatives via Ugi reaction

Combinatorial chemistry is now routinely applied to find outnovel biologically active compounds. In this context, multicomponentreactions (MCRs) are powerful tools in the modern drug discoveryprocess in terms of lead finding and lead optimization.Special subclasses are isocyanide-based MCRs (IMCRs).Today, most MCR chemistryperformed with isocyanides is related to the classicalreactions of Passerini [1] and Ugi [2]. Ugi reaction played an important role in organic and medicinal chemistry due to the importance of the resulting α-amino acyl amide and several bioactive natural products [3]. In continuation of our recent research on development of novel multicomponent reactions,[4] we report, herein a simple, facile, rapid, and efficient four-component for the preparation of some new 2-acetamido-N-(2-(cyclohexylamino)-2-oxo-1-phenylethyl)-N,3- diphenylacrylamide 5via ugi reaction between alaldehyde 1, amines 2, isocyanides 3, and 2- acetamido-3-phenylacrylic acid4 for the first time.(Figure 1).