Synthesis of triacetoxybenzoic acid and triacetoxybenzoyl chloride from Gallic Acid and study on comparison of their Antibacterial Activity

Gallic acid (GA) or 3,4,5-trihydroxybenzoic acid is a polyhydroxy phenolic compound and found in various plants such as tea, green tea and fruits [1].Variousderivatives of gallic acid have shown good bioactivity including antibacterial, antifungal, antiviral, anticancer, antioxidant, antitumor activities [1,2].In this study, we first synthesized triacetoxybenzoic acid(ACGA) and 3,4,5-triacetoxybenzoyl chloride(ACGACl) from GA and then evaluated the antibacterial activity of the synthetic compounds against nine microorganisms using disc diffusion method and compared with the GA activity The three compounds prevented the growth of all the microorganisms. However the activity of GA was more potent than its derivatives. The results as diameter of inhibition zone in term of millimeter (mm) are shown in the table 1. The decreasing of ACGA and ACGACl activity may be due to changing of hydroxyl groups to acetoxy and chloride..