چكيده فارسي :
2-Amino-4H-chromenes are of particular utility as they belong to privileged medicinal scaffolds serving for generation of ligands with a broad spectrum of potent biological activities that include anti-microbial, anti-tumor, anti-cancer, anti-viral,antimalarial, anti-proliferative, and anti-alzheimer‘s [1]. Also, the azo dyes are one of the major groups of synthetic organic dyes with broad range of biological activities [2, 3]. The new chromene-based azomethine dyes were synthesized via two-component coupling of 2-amino-7-hydroxy-4H-chromene with 2-hydroxy-5-(aryldiazenyl)benzaldehyde and characterized by elemental analyses, mass, NMR, IR, UV–Vis spectroscopy and X-ray diffraction analysis. Easily available and easy work-up are the key features of the present method. The pyran, chromene moiety and aromatic rings in the azomethine linkage are flattened. Intramolecular hydrogen bonding is possible between hydroxyl group and the imine nitrogen atom.
