Triethylammoniumtrinitromethanide[TEATNM] as a novel ionic liquid catalyst for the synthesis of 2-amino-4-aryl-6-(arylamino)pyridine-3,5-dicarbonitrile derivatives

The pyridine ring plays a main role in numerous biological processes, most remarkably in the oxidation/reduction cofactors such as: NADPH, NADH, NADH and NAD+; the vitamin niacin is required for its biosynthesis.1 3,5-Dicyanopyridines have been applied as intermediates in the synthesis of pyrido[2,3-d]pyrimidines as antihistaminic agents, pyridothieno- and pyridodithienotriazines endowed with antihistaminic and cytotoxic activity and acyclo-3-deazapyrimidine S-nucleosides that are active toward HIV.2 Triethylammoniumtrinitromethanide [TEATNM] as a novel ionic liquid catalyzed the synthesis of 2-amino-4-aryl-6-(arylamino) pyridine-3,5-dicarbonitrile derivatives via the One- Pot three-component condensation reaction between various aromatic aldehyde, malononitrile and aniline derivatives at 50 oC under solvent-free conditions. The synthesized ionic liquid catalyst was fully characterized by using FT-IR, 1H NMR, 13CNMR, Mass and thermal gravimetric (TG) analysis. The major advantages of the described methodology are ease of separation, good yields and short reaction times.The scope and limitations of the described methodology will be discussed.