Cyclohexane-1,4-diyl bis(hydrogen sulfate): A highly biocompatible catalyst for synthesis of pyrimidines

Pyrimidines have occupied an important place in organic and medicinal chemistry, mainly due to their diverse therapeutic and pharmacologicalproperties [1]. Among them, fused pyrimidines have been used as a common source for the synthesis of new therapeutic agents. Recent studies have shown that pyrimidine-fused heterocycles, particularly their oxo and thioxo derivatives, possess a wide range of biological activity and for this reason, they are extensively used in the design of new drugs [2].The synthesis of pyrimidine derivatives by a multicomponent reaction (MCR) is an attractive approach for the construction of this class of compounds [3]. It has been proven recently that this is a mild, worthwhile catalyst, which is efficiently and selectively catalyzes various organic transformations and synthesis. The catalyst was recovered activated and reused for two consecutive times with only slight variation in the yields of the products. Now, we report an efficient and convenient procedure for the One-Pot synthesis of aromatic aldehyde, barbituric acid and aromatic amine, by using homogeneous catalyst cyclohexane-1,4-diyl bis(hydrogen sulfate) [CDBH]to produce the pyrimidine-fused heterocycle derivatives in excellent yields (Figure 1).