پديدآورندگان :
Zakerzadeh Elham Elhamzakerzadeh@gmail.com Azarbaijan Shahid Madani University , Mahkam Mehrdad Azarbaijan Shahid Madani University , Salehi Roya Tabriz University of Medical Sciences, Tabriz
چكيده فارسي :
Tetrazole is a cyclic and aromatic compound including a carbon and four nitrogen atoms in
a five-membered ring. In the category of heterocyclic compounds, tetrazole derivatives, in
particular 5-substituted tetrazoles, are successfully utilized in medicine, biochemistry,
agriculture and fine organic synthesis. Also a large number of medicinally important tetrazole
heterocyclic incorporated drugs such as antihypertensive, antihistamine, diuretics,
antiparasitic, anticancer drugs, inhibitors of thrombosis, and drugs with anti-inflammatory,
anesthetic, antifungal, tuberculostatic and antiviral activity approved by the FDA [1].Smart
carriers can increase the penetrance and survival of drugs in tumors and decrease the side
effect and toxicity related with most anti-cancer drugs. Introducing different stimulusresponsive
properties to DDSs is an efficient way to achieve these goals [2].Cancer cells can
develop resistance to chemotherapy drugs, but are less likely to develop resistance when
multiple drugs are delivered simultaneously. However, different drugs target different parts of
the cancer cell [3].In this research a novel antibacterial polymeric nano-system was developed
for combination cancer therapy. The synthesized nanocarrier was fully characterized and its
antibacterial activity was assessed by MIC values against some bacterias and funguses.DOX
and MTX as anticancer drugs were conjugated concurrently to nanocarrier with an
encapsulation efficiency of about 95% and sustained the release of both drugs up to 20 days
with apparent pH-triggered controlled release manner. Cell viability tests affirmed that the coadministration
of DOX with MTX lead to an efficient anticancer performance to MCF7 cell
lines verified by MTT assay test.
