Furanocomarin from the root of ferulago carduchorum (BOISS. HAUSSKN.)

Ferulago carduchorum is a perennial herb of Apiaceae, which is endemic of Iran distributed in central part of Iran.chevil, is the common name for the plant in Iran [1]. Ferulago carduchorum has been used throughout history as sedative tonic and for treatment of ulcers, hemorrhoids, spleen disease, digestive panics, headache, and snake bite [2]. In the present work, the plant materials were collected from Kuhkiloye ve Boyer Ahmad province.Airdried and powdered plant roots were extracted with n-hexan, dichloromethane and methanol, respectively, using a soxhlet apparatus. The n-hexan extract was fractioned with VLC technique and after primary test with analytical TLC, best fraction was extracted with column chromatography (CC).In next stage, best fraction was subjected to preparative thin layer chromatography. (P-TLC) using chlorophorm: aceton (91:9) as solvent system to yield one linear furanocoumarin named prantschimgin.The structure of isolated compound was elucidated by spectroscopic data such as HNMR,CNMR,UVand IR.Up to our knowledge, this is the first report on root phytochemicals of F.carducrum.It was assumed that biological and pharmacological activities of the plant might be contributed to the presence of furanocoumarins.The comparison of our results with the literature showed that prantschimginispresented in other species of the genus and could be used as a chemotaxonomic marker of the genus.