Magnetic catalyst oxidative coupling of carboxylic acids with N,N,Dialkylformamides:an Approach to the synthesis of Amides

Amides linkages (-CONH-) are widely found in nature and play significant role in biological systems and in the fields of pharmaceuticals,natural products and polymers[1].Although several attractive approaches involving a non-carboxylic acids rout have been reported over the last few decades[2].In recent years ,cross dehydrogenative couplings or oxidative cross-couplings have becameapowerful synthetic strategy in organic chemistry[3].Formamides are known to be useful as solvents and oxygen in metal-catalyzed organic reactions.In this most methods use for this purpose,homogeneous catalysts have been employed.Due to their improved efficacy,homogeneous catalysis has received more attention and consideration than heterogeneous approaches.In this study we examinedamid synthesis by oxidative coupling of carboxylic acids with N,N-dialkylformamides in the presence of cu(II)acetate complex immobilized on the surface of magnetic nanoparticles as an efficient and magnetically seperablecatalyst.The magnetic catalyst was charactrized by FT-IR, SEM, VSM, XRD, EDX.