چكيده فارسي :
Generally the classical synthetic methodologies involve expensive reagents and catalysts,
which are not easily available and require harsh reaction conditions. Thus there is need to
replace such reagents and catalysts. The threat to ecological and environmental synthesis due
to the damages caused by the chemicals has put forward a new area of the so called ―Green
Chemistry‖ that ionic liquids are incncept. Currently protic ionic liquids (PILs) have got
popularity due to their extensive liquid temperature range, ionic conductivity and high
thermal stability, which is ample for practical applications PILs, usually synthesized by the
neutralization reaction of Bronsted acid and base, establish one of the most vital classes of ILs
[1]. The development of new anti-cancer treatments with greater efficacy and fewer side
effects remains a significant challenge of modern scientific and medical research. Curcumin, a
natural polyphenol found in the dietary spice turmeric, has been demonstrated to inhibit
cancer cell survival and proliferation, and to induce apoptosis without promoting the
development of side effects[2]
We have successfully developed a simple and an efficient method for the synthesis of
curcumin derivatives under solvent-free conditions by the condensation of various aromatic
aldehydes, using cheap and readily available EDAHS as a protic ionic liquid catalyst. For this
purpose, a mixture 4-methylbenzaldehyde (0.24 mL, 2 mmol) and 1,3-diketones (0.13 mL, 1
mmol) was treated with EDAHS (0.026 gr, 0.1mmol) at 70 °C for 40 min.When the starting
aldehyde had completely disappeared, the reaction mixture was quenched by adding H2O (10
mL) and filtered..
