One-pot Three Component Synthesis of Some New Dihydropyrimidines Derivatives

In recently years dihydro pyrimidines were attention of many chemists and biologists and their analogues have a wide range of biological activities, such as antiviral, antitumor and antimicrobial agents [1]. Several methods have been reported for synthesis of dihydro pyrimidines in different conditions [2]. In the context of our ongoing studies on synthesis of heterocyclic compounds[3],herein, we wish to report a novel, efficient, and One-Pot method for the construction of some new dihydro pyrimidines via condensation ofbrimonidine 1, malononitrile 2, and aldehyde 3 derivatives using the non-toxic and easily available Alum as a heterogeneous catalyst(Figure 1).