Organically functionalized mesoporous silica nanoparticles as an effective nano-carrier for curcumin delivery

In this study, the synthesis of novel PEGylatedimidazolium ionic liquid and Citric PEGylated functionalized MSN nanoparticles and also the evaluation of their potential in the loading and release of curcumin have been investigated. Due to the high surface area and their capability for the desired organically functionalization, their application provide convenient opportunity to introduce high efficient nano-carriers. The size, the loading amount and release efficiency were investigated in in-vitro conditions. Techniques such as BET, XRD,DLLS, UV-Vis, TGA, FT-IR and TEM were applied for characterization. Herein, a PEGylated functionalized imidazolium ionic liquid and Citric PEGylated functionalized MSN nanoparticles has been fabricated. Then it has been evaluated as an effective nanocarrier for improving the transport and delivery of CUR to cancerous cell lines. Indeed the structure of PEGylatedimidazolium ionic liquid and Citric PEGylated functionalized MSN nanoparticles was fully characterized and confirmed by a variety of techniques. Then CUR was loaded on the surface of the modified NPs. MTT assay technique was applied to examine the efficiency of PEGylatedimidazolium ionic liquid and Citric PEGylated functionalized MSN nanoparticles as anticancer. Our data suggest that CUR loaded PEGylatedimidazolium ionic liquid and Citric PEGylated functionalized MSN nanoparticles has more cytotoxic effect on MCF-7 as the cancerous model cell versus pure CUR.