چكيده فارسي :
Heterocyclic compounds have increasing important in the pharmaceutical industry and the
most of important life-science products are contain heterocyclic structures [1].
Perhalogenated pyridines have a broad chemistry that arising from replacement of halogen
atom by various nucleophiles via aromatic nucleophilic substitution reaction.Halogen
substituents atdifferent positions of heteroaromatic systemsring indicate different reactivity
tonucleophiles, for example reaction of various nucleophiles with pentachloropyridine [2] and
pentafluoropyridine [3]reported in detail.Regiochemistryof nucleophilicsubstitution reactions
is depend on the nature of nucleophile, reaction condition, and solvent [4].Herein we wish to
report the solid phase synthesis of some substituted diheteroaryl sulfide from reaction of some
fluooro- and chloro-heteroaromatic 1 compounds in porcelain mortar with of 4,6-
diaminopyrimidine-2(1H)-thione2 for 15 min at room temperature. The structure of
compounds were confirmed with 1H-NMR,13C-NMR and19F-NMR spectroscopy.
In conclusion, we have shown that some substituted diheteroaryl sulfide could be
synthesised from chemoselectiv reaction of 4,6-diaminopyrimidine-2(1H)-thionevia S
nucleophile site with some fluooro- and chloro-heteroaromatic compounds.
