پديدآورندگان :
Bahmani Zahra Ahvaz Branch,Islamic Azad University , Badri Rashid RashidBadri@Yahoo.Com Ahvaz Branch,Islamic Azad University
چكيده فارسي :
The synthesis of substituted and condensed indoles has attracted considerable attention due
to their importance as building blocks for many therapeutically useful materials and the wide
ranging biological activity of both synthetic and naturally occurring derivatives1.
Tetrahydrocarbazoles condensed with indole, furan, pyrimidine, pyrazoline, and
thiophene,moieties have been known to processes wide spectrum biological activities.There
has been many methods of synthesis which includes cyclization of diphenylhydrazone of
cyclohexane-1,2-dione or 2-phenylhydrazono cyclohexanone via Fischer indole synthesis2.
However the Bischler synthesis served as one of the simplest and attractive method to obtain
tetra hydrocarbazoles and carbazoles by the condensation of α-halocyclohexanones with
aromatic amines3. Improved method for the synthesis of tetrahydrocarbazoles by the Bischler
reaction was also reported. Hence in this work, we report the application of sulfanilic acid as a
catalyst for efficient One-Pot Fischer phenyl hydrazine whith cyclohexanone synthesis of
tetrahydrocarbazoles and by using methanol solvent in summary, involving rapid mild and
high yielding product with good purity and excellent yields and also for the simple synthesis
of new hetrocycles via modifications of existing methodologies and their biological
activities.(Figure1)
