پديدآورندگان :
Tosan Fatemeh tosan_fatemeh@yahoo.com Department of Chemistry, Islamic Azad University, Science and Research Branch, Tehran, Iran , Hashemi Mohammad M. tosan_fatemeh@yahoo.com 1Department of Chemistry, Islamic Azad University, Science and Research Branch, Tehran, Iran
2Department of Chemistry ,Sharif University of Technology,Tehran, Iran. , Kobarfard Farzad tosan_fatemeh@yahoo.com 3Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical
Sciences, Tehran, Iran.
4Centeral research laboratories , Shahid Beheshti university of medical science ,Tehran, Iran.
كليدواژه :
acid , piperidine , aryl hydrazone , Antiplatelet , platelet Aggregation
چكيده فارسي :
A strategy toward the synthesis of a series of aryl hydrazones substituted 1-benzylpiperidine-3-carboxylic acid derivatives , bearing various selected substituents on both the piperidine ring nitrogen and the hydrazide nitrogen, a class of compound with potential antiplatelet aggregation activity was developed. Aryl hydrazones derivatives of 1-benzylpiperidine-3-carboxylic acid were synthesized in five-step, starting from nicotinic acid and their anti platelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid (AA) and collagen were used as inducers of platelet aggregation.
