Investigation of Fluid-Structure interaction effect on Low-Density Lipoprotein (LDL) penetration into multilayer arterial wall

Heart attacks and brain strokes are two of the main death causes in the world and therefore, their genesis and development are of a great medical importance. Lipid deposition in arterial wall which leads to the decrease of the blood flow in a gradual process is known as the main reason of these strokes. An axisymmetric five-layer arterial wall including endothelium, intima, Internal Elastic Lamina (IEL), media and the impermeable adventitia layer is modeled in the present study. The effect of fluid-structure interaction on low-density lipoprotein (LDL) transport into arterial wall is investigated. The result shows drastic increase of LDL concentration in the compliant artery walls comparing to the rigid model, especially at high transmural pressures.