Design of a MEMS-Based Magnetophoresis MicroSeparator

Design and investigation of a micro-Electro-Mechanical System (MEMS) based fluidic separator for high gradient Magnetophoresis cell separation (HGMCs) is the main goal of our study. The HGMC separation effect is achieved by using ferromagnetic materials in the mechanical structure. We proposed a standard lithography process with SU8 spin coating on a quartz substrate for fabrication process. In our study we choose new layout of soft irons which increases the gradient of magnetic field. This effect provides highly efficient magnetic field patterns at the separation zone and as a result effective magnetic force on magnetic beads. Our study reveals that the proposed technique is able to separate T+CD4 cells from blood components and eases the final numeration process. Rapid separation and low cost are the main is the main advantages of our design. Our introduced MEMS based magnetophoresis separator with an external applied magnetic field, separation time of under 14s, and 100% separation of target cells.