چكيده فارسي :
Electromembrane extraction (EME) is an analytical microextraction technique (a liquid-phase microextraction concept), where charged analytes are extracted from an aqueous sample, through a supported liquid membrane (SLM) comprising a water immiscible organic solvent, and into an aqueous acceptor solution. The driving force for the extraction is an electrical potential (dc) applied across the SLM. Target analytes are typically drug substances and aqueous samples are biological fluids such as whole blood, plasma and urine. The SLM comprises an organic solvent immobilized by capillary forces in the pores of a porous polymeric membrane. This porous polymeric support can be a flat sheet or a hollow fiber membrane. EME is well-suited for pharmaceutical analysis but environmental and food applications are also reported frequently. This concept was published for the first time in 2006 [1]. Since the introduction, close to 250 research papers have been published on EME, and the last couple of years, nearly 50 research papers have been published per year. The publication frequency is positive and EME is an active research area which has been reviewed several times in recent years [2-4]. In this presentation, electromembrane extraction will be reviewed. The purpose is to review the most recent literature, give a flavor of the most recent development and address one very important question; what are the future directions and perspectives of EME? First, the principle for EME will be explained with a focus on extraction of cationic and anionic analytes and typical performance data will be presented. Second, selected papers published in 2016 and 2017 will be reviewed and discussed with a focus on (a) new SLMs, (b) new support materials for the SLM, (c) new sample additives improving extraction, (d) new technical configurations and (e) new analytical applications. Then, important future research perspectives and directions will be proposed for further development of EME. Finally, a selected original research paper published by our group in 2017 with subject of the modification of EME performance via sol-gel strategy for extraction and quantification of an important anticancer agent, Imatinib mesylate, in human plasma using field-amplified sample injection-capillary electrophoresis (FASI-CE) will be discussed.
