Development of nonenzymatic glucose sensor based on graphene nanosheet/ cetyltrimethylammonium bromide/Cu(OH)2 nanoparticles composite

The development of rapid, simple and reliable methods of monitoring glucose is important in many areas such as clinical diagnostics, medicine and food industry[1]. Therefore, the development of a cheap, sensitive and interference free sensor for non-enzymatic glucose detection is still greatly demanded.In this work, a new nanocomposite (graphene nanosheet/ cetyltrimethylammonium bromide (CTAB)/ Cu(OH)2 nanoparticles (GNs/CTAB/ Cu(OH)2NP) was deposited on glassy carbon electrode. The obtained electrocatalyst was characterized by scanning electron microscopy and cyclic voltammetric techniques. The electrocatalytic activity of the modified electrode for the oxidation of glucose, in aqueous basic solution was studied by using cyclic voltammetry. The sensor can effectively improve electron transfer efficiency and enhance electrocatalytic activity toward glucose, based on synergistic effect of Cu(OH)2 nanoparticles, CTAB and graphene nanosheet. The kinetic parameters of the electron transfer coefficient (α) and number of electrons involved in the rate determining step (nα) for the oxidation of glucose were determined utilizing CV. Electrochemical measurements demonstrate that the GNs/CTAB/ Cu(OH)2NP /GCE, when used as a non-enzymatic glucose sensor, offers superior analytical performances with a wide linear range (from 5 μM–10 mM), and low detection limit (2.7 μM, signal-to-noise = 3). The main advantages of sensor include simple and green fabrication approach, roughed and stable electrode matrix, high sensitivity and stability, fast in sensing and highly reproducible.