Preparation and optimization of nano zeolite ZSM-5 using of experimental design and spectroscopy and its modification with β–cyclodextrin as carrier for curcumin

This study was performed in order to prepare and optimizeZSM-5nano and its modification by β–cyclodextrin as a carrier for curcumin anti-cancer drug. Nanosized ZSM-5 zeolite was synthesized to study the optimum conditions of synthesis based on a fractional factorial experimental design, by hydrothermal method.The samples were synthesizedwithout organic template and different conditions such as molar composition of the synthesis gel andaging time were studied in a wide range [1]. Then nano zeolite was modified with β–cyclodextrin [2]. Characterization of nanoparticles was performed by SEM, FT-IR and TGA. Scanning electron microscopy showed that the smallest particle size is approximately 44 nm. FTIR and TGA confirmedsynthesis and functionalization of zeolite nanoparticles with cyclodextrin. Then a drug delivery system (DDS) was prepared based on cyclodextrin-modified zeolite with curcumin anticancer drug and its formation was studied under experimental conditions [3]. Efficiency of loading and drug release were both determined by UV-Vis Spectrophotometry. The drug loading on the surface of the nanoparticles in optimal conditions was 95%and efficiency of drug release was evaluated 43% in pH=7.4 and 61% in pH=5.5. This indicates that performance of the drug delivery system in tumor tissues is higher than healthy tissues. Thus the synthesized nano carrierwould provide an appropriate approach for the delivery of hydrophobic drugs to the target tissue such as curcumin that has sub-optimal pharmacokinetics and poor bioavailability.