Case studies in human, animal and regulatory toxicology –possible linkages

Agrochemical and drug poisoning is a leading cause of death in people under 65. One of our key interests is in understanding the nature of those poisonings and how to assess and treat patients exposed to these poisons. Underpinning these interests are the use of cell and animal studies to understand the nature and to predict the potential outcome of the poisonings based on scaling from animals to man using allometric and physiological pharmacokinetics techniques. In this presentation, I outline the scope of our work in this area, provide some examples of our clinical case studies and discuss some of the insights we have gained or are gaining from mechanistic rodent and sheep pharmacokinetic and toxicology studies. A key outcome from this work is a recognition that we need to increase collaboration across toxicology and encourage multi-disciplinary toxicological research to increase translation into improved human and animal health outcomes leading to appropriate regulation, product usage and public-health interventions.