Protective Effects of Camel’s milk on Aminoglycoside –Induced Nephrotoxicity in an Animal Model

Gentamicin is an effective aminoglycoside antibiotic that is well established for the treatment of several bacterial infections, especially those caused by Gramnegative bacteria, including Pseudomonas aeruginosa, Klebsiella species, and Serratia marcescens .but the risk of nephrotoxicity and oxidative damage limit its long-term clinical use. The aim of the present study was to assess the protective effect of camel’s milk against gentamicin induced nephrotoxicity. Four groups of six male albino rats were used. Group I served as control and received only normal saline injections (100 mg/kg, i.p.). Group II was given fresh camel s milk only (5 mL/rat/day for fifteen days, orally). Group III was injected with Gentamicin (2mL vials) only (100 mg/kg b.wt for the last ten days, i.p.). Group IV was given camel s milk (alone for first five days) and then injected with Gentamicin (for 10 days). Animals were euthanized by an excess dose of the ether, kidney removed for histopathological study. The results showed that in comparison with control rats, gentamicin produced tubular, glomerular and interstitial alterations that included degeneration, necrosis, cytolysis and cortical tubular desquamation together and blood capillary congestion. However camel’s milk had protective effects on nephrotoxicity (p 0.05). The present study demonstrated the renoprotective potential of camel’s milk against Gentamicin-induced oxidative stress and renal dysfunction in rats and hence camel milk can be identified as a new therapeutic agent.