پديدآورندگان :
Hosseini SM Assistant professor of pathobiological department, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran , Amani R Veterinary student and member of Young researcher club and elite, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran , Razavimehr SV 2Veterinary student and member of Young researcher club and elite, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran , Moshrefi AM Veterinary student and member of Young researcher club and elite, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran , Aghajanikhah MH Veterinary student and member of Young researcher club and elite, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran , Ahmadi AA North Research Center, Pasteur Institute of Iran, Amol, Iran , Behzadi R North Research Center, Pasteur Institute of Iran, Amol, Iran , Kavousian S North Research Center, Pasteur Institute of Iran, Amol, Iran , Molaei ghara K kamran.molaeii@yahoo.com Veterinary student, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran
كليدواژه :
Phosphorus , Rat , Nanoparticles , Toxic effects , ZnO
چكيده فارسي :
Objectives: Zinc oxide (ZnO) is toxic; It is likely that increased industrial production will lead to human contact (dermal, inhalational, and ingestion) and exposures. The release of nanoparticles into the environment can increase the exposure Ecosystem. The aim of this study was to evaluate the toxicity of different doses of zinc oxide nanoparticles on blood phosphorus in wistar rats.Materials Methods: Rats with 150-200 grams of weight were divided into seven decuple groups including control, sham treated with saline and five groups Injected with different doses of zinc oxide nanoparticles (4, 8, 25,100 and 200 mg/kg twice a week for four weeks). All groups were placed in a controlled environment with 22°C, 60% humidity, 12 h light and darkness and free access to food and water. Blood samples were sent to laboratory for phosphorus measurements.Results Conclusion: The highest of blood phosphorus was detected in 100 and 200 mg/kg experimental groups that had a significant difference with other groups. (p 0.05) This study showed that different doses of ZnO nanoparticles lead to Increases blood phosphorus levels in female rats. It seems that renal pathological lesions of ZnO nanoparticles lead to changes in blood phosphorus levels. ,
