پديدآورندگان :
Hosseini SM Assistant professor of Pathobiological Department, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran , Amani R Veterinary Student and Member of Young Researcher Club and Elite, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran , Aghajanikhah MH Veterinary Student and Member of Young Researcher Club and Elite, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran , Razavimehr SV Veterinary Student and Member of Young Researcher Club and Elite, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran , Moshrefi AH Veterinary Student and Member of Young Researcher Club and Elite, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran , Sokooti Z Assistant professor of Pathobiological Department, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran , Vahidirad M mehdi.vahidirad@yahoo.com Assistant professor of Pathobiological Department, Faculty of Veterinary Medicine, Islamic Azad University of Babol, Babol, Iran
كليدواژه :
Na , K , Rat , Nanoparticle , Toxic effect
چكيده فارسي :
Objectives: Significant increased production and use of ZnO is leading to a greater probability for release of Zno into the environment and exposure to organisms. Pathological observations confirmed ZnO nanoparticles have severe toxicological effects on kidney. In this study, we investigate ZnO nanoparticles toxicity on imbalance of blood Na and K levels subsequent of kidney damage in wistar rats.Materials Methods: For this study, 70 wistar rats weighting 150-200 g were purchased and divided into 7 groups (ten rats in each group) including control, sham and five injected groups by 4, 8, 25, 100 and 200 mg/kg of ZnO nanoparticles twice a week for four weeks. For measurement ¸blood samples were collected and transferred to laboratory.Results Conclusion: With increases Zno nanoparticles blood levels of Na in 200 mg/kg experimental groups had a significant difference with other groups. Increased blood level of K as result of increases Zno nanoparticles. 100 and 200 mg/kg doses had a significant difference with control and sham groups. (p 0.05) Blood electrolytes increased as a result of liver and kidney damage. Subsequent of blood Na and K imbalances osmotic pressure and liquid disorder occurs,
