antioxidant effect of hydroalcoholic satureja bachtiarica extract against ethanol-induced gastric ulcer in rat

Objectives: Ethanol is known to induce gastric ulcer by oxidative effect in mucus. Materials Methods: The adult female wistar rats were divided into 7 groups with 5 rats in each group. We studied the antioxidant effect of hydroalcoholic satureja bachtiarica extract (with doses 200,400,800 mg/kg) and omeprazole (with doses 20 mg/kg) prevent gastric ulcer drugs used in this study were given by gavages. The rats were anestizied with ketamine and xylazine 1 hour later. The animals were killed then after abdomen insicion were bled from the hearts and stomachs were outside. Stomachs were washed with normal saline and fixed to measuring ulcer index and histological examination, then serum harvested by centrifugation and SOD measured by ELIZA kit.Results Conclusion: The extract concentration of 800 mg/kg of 65.78 percent showed a protective effect that compared with the Omeprazole inhibits the rate of wound healing 62.89 percent had a good performance. The ulcer index with respect to 6.74 of 7.31 extract showed a significant effect And the level of superoxide dismutase (SOD) in the extract with a concentration of 800 mg kg, SOD amount equal to 26.44, which was 24.05 further showed that omeprazole.The main constituents of the extract were thymol and carvacrol, which can be viewed on the antioxidant effects do play a part. Due to the antioxidant effects observed in oxidative stress by ethanol, the Satureja bachtiarica can be considered in the treatment and prevention of gastric ulcers.