Simultaneous determination of epinephrine and folic acid using Fe3O4@Sio2-GO nano composite modified graphite screen printed electrode

Nanocomposite materials have shown promising applications in the interdisciplinary research areas with significantly improved activity because of the synergistic contribution provided by the constituent components of the nanocomposite material[1]. Epinephrine (EP) belongs to the family of catecholamine neurotransmitters, which is widely distributed in the mammalian central nervous system for message transfer process[2]. It is also called as flight or fight hormone. High levels of EP are associated with stress and thyroid hormone deficiency [3]. Folic acid (FA) is a widely distributed water-soluble vitamin and can act as a coenzyme that controls the generation of ferroheme[4]. FA paucity mounts to gigantocytic anemia, neurosis, mental decentralization, leucopoenia, etc. FA determination is essential in pharmaceutical, clinical and food samples[5]. Electroanalytical methods have attracted more attention in recent years for environmented and biological compound determination due to their sensitivty, accuracy, low cost and simplicity [3]. The present study is aimed at synthesis of Fe3O4@Sio2-GO nanocomposite and its application in the form of modified graphite screen printed electrode for trace, rapid and sensitive determination of EP and FA by using this modified eletrode EP and FA were determination in the range of 1-1000 μmol L−1 and 0.1-1000 μmol L−1 respectively.