An indirect electrochemical determination of thioacetamide by using of Ag@Fe3O4 nanoparticle modified carbon paste electrode

Tahiocetamide (TAA), is a widely used sulfur-containing compound both in the laboratory and in various technical applications and can also be present in the environment as organic sulfur compounds. TAA is used as a replacement for hydrogen sulfide in qualitative analyses and in hospital practice, as an accelerator in rubber vulcanization, as a reductant additive in the leather, textile and paper industries, generally having a similar role to thiourea. The widespread uses of TAA are unavoidably accompanied by its toxicity and a number of ecotoxic effects in environmental pollution can result from TAA manipulation and its consequent presence in waste waters. These aspects become increasingly important due to high degree of hepatic and neurotoxic injury, and carcinogenity, of TAA, which has been demonstrated under various experimental conditions. Thus, in these circumstances the detection of thioacetamide in real time has become more and more important [1]. Electrochemical methods are simple and versatile due to their advantages such as cheap instrumentation, quick response time, high sensitivity and wide linearity. In this work an electrochemical sensor was proposed for the determination of thioacetamide. For this propose Ag@Fe3O4 nanoparticles [2] were applied as an effective modifier for the modification of carbon past electrode. TAA can form the self-assembled monolayers (SAMs) on the surface nanoparticles and decrease the peak current of the modified electrode. Under the optimized condition, the linear range and detection limit were obtained as 50-100 nM and 32.58 nM, respectively. The obtained results for the determination of TAA by this method, showed, excellent analytical performance for the determination of thioacetamide in terms of an appropriate detection limit, high sensitivity, very good accuracy, repeatability and reproducibility.