Voltammetric Determination of Bisphenol A Using a Modified Screen-Printed Carbon Electrode Modified With Nanocomposite

Bisphenol A (BPA) is one of a number of potential endocrine disruptors. BPA could potentially interfere with the endocrine system of both the wild animals and humans, reduce immune function, cause cancer and impair reproduction even at concentrations as low as the 10–25 nM level. BPA is used as a monomer in synthesis of polycarbonate plastics, epoxy resins, flame retardants, polystyrene resins and other specialty products which are widely used for inner coating of dental composites, food cans and drug delivery systems. [1]. Screen-printed carbon electrodes (SPCEs) are acknowledged to be very effective devices for the determination of different kinds of analytes in biomedical, environmental, and industrial samples [2]. Electrode modification using nanoparticles (NPs) has grown exponentially. In particular, nanoparticles have been studied extensively for the design and fabrication of catalysts, an enhancement of catalytic activity or selectivity, the large surface area-to-volume ratios, and good conductivity [3]. The relevance of Bisphenol A (BPA) in human health is well-known. For this reason we designed and developed a biosensor based on a nanocomposite modified screen printed carbon electrode. Nanocomposite modified electrode shows a higher catalytic response and lower overpotential for BPA. The lowest limit of detection (LOD) of 0.57 μM is able to be achieved using NPs/SPCE electrode. The sensor showed very good sensitivity along with an excellent operational stability.