پديدآورندگان :
Zaboli M. Under Graduate Student, Veterinary Faculty, Shahid Bahonar University of Kerman, Iran. , Hashemian A. Under Graduate Student, Veterinary Faculty, Shahid Bahonar University of Kerman , Pouramin A. Under Graduate Student, Veterinary Faculty, Shahid Bahonar University of Kerman, Iran , Sayedin S. Under Graduate Student, Veterinary Faculty, Shahid Bahonar University of Kerman, Iran , Nazem MN Associate Professor of Veterinary Faculty, Shahid Bahonar University of Kerman, Iran
كليدواژه :
Protein malnutrition , Salivary gland , rat , Diazepam , Pilocarpine
چكيده فارسي :
Abstract: Disturbances of the in utero environment may program for disease in later life. Exposure to a diabetic environment in utero is associated with a high risk of obesity and glucose intolerance. The submandibular glands of the offsprings of diabetic mothers revealed remarkable changes in serous acini and duct system throughout the experimental periods compared to the offspring of the control group. There was a significant increase in the total surface area of acini and ducts of the rat submandibular gland during the two and six weeks of postnatal life in comparison to the corresponding values of the control group. Conclusion: Maternal hyperglycemia revealed histomorphological changes in submandibular glands during postnatal period and hence maternal diabetes can be considered a very important risk factor to the development and growth of submandibular glands [1]. Four weeks old male mice were given a diet containing 2-5 % protein for a period of four weeks and its effects were compared with those in similar animals which were given a 20% protein diet. The protein-deficient animals were found to have a markedly reduced body weight compared to the controls. This was accompanied by a significant reduction in the mean cell volume of the granulated convoluted tubule cells of the submandibular gland. The acinar cells also showed some reduction in size [2]. Benzodiazepines are among the most frequently prescribed drugs and are often related with dry mouth. Pilocarpine is a cholinergic agonist that increases salivary flow rate and has been used to treat xerostomia. Seventy-two male Wistar rats were allocated to four groups. Control groups received saline during 60 days (C60) and pilocarpine (Pilo) during 60 days. Experimental groups were dealt with Diazepam® associated with saline (DS), and Diazepam® associated with pilocarpine (DP) during 60 days. Psychotropic drugs caused hyposalivation in rats and acinar hypertrophy in their parotid glands. Pilocarpine, a cholinergic agonist with topical appliance, showed significant secretagogue action in the treatment of hyposalivation induced by Diazepam® chronic use. [3]
