كليدواژه :
يسوتوكسين , داروي ضد سرطان , پلي اتر دريايي , دوتاژكي ها
چكيده فارسي :
يسوتوكسين يك تركيب پلي اتر دريايي است كه اولين بار در ژاپن در سال 1986 به دست آمد. اين تركيب به عنوان يك محصول در بدن تك سلولي هاي دوتاژكي و صدف ها يافت مي شود . يسوتوكسين خواص دارويي بسيار عالي اي براي درمان سرطان هاي مختلف از قبيل سرطان سينه ، سرطان فك بالايي و ... دارا مي باشد. در اين مقاله مروري بر خواص، تركيب و كاربردهاي يسوتوكسين و تركيبات مشابه آن خواهيم داشت و پتانسيلهاي كاربردي اين مواد طبيعي را به عنوان يك ماده اوليه در درمانهاي دارويي و شيميايي بررسي خواهيم كرد.
چكيده لاتين :
Yessotoxin (YTX) is a marine polyether toxin that was first isolated in 1986. This compound found in scallops and dinoflagellates bodies. YTX acts as a great drug for treatment of cancers such as breast, neuroblastoma, … . In this paper, we explain structures, properties, applications analogues of YTX and it’s great potential as a compound for chemical treatments. YTXs have been associated with diarrheic shellfish poisoning (DSP) because they are often simultaneously extracted with DSP toxins, and give positive results when tested in the conventional mouse bioassay for DSP toxins. However, recent evidence suggests that YTXs should be excluded from the DSP toxins group, because unlike okadaic acid (OA) and dinophyisistoxin-1 (DTX-1), YTXs do not cause either diarrhea or inhibition of protein phosphatases. In spite of the increasing number of molecular studies focused on the toxicity of YTX, the precise mechanism of action is currently unknown. Since the discovery of YTX, almost forty new analogues isolated from both mussels and dinoflagellates have been characterized by NMR or LC-MS/MS techniques. These studies indicate a wide variability in the profile and the relative abundance of YTXs in both, bivalves and dinoflagellates. This review covers current knowledge on the origin, producer organisms and vectors, chemical structures, metabolism, biosynthetic origin, toxicological properties, potential risks to human health and advances in detection methods of YTXs.
