Synthesis and characterization of a new pharmaceutical co-crystal [(caff)(gen)] by sonochemical method

Co-crystal is crystalline structure consisting of two or more components that form a unique structure having specific properties [1]. Th e components in a co-crystal exist in a definite stoichiometric ratio, and assemble via non covalent interactions such as hydrogen bonds, ionic bonds, and π-π or van der Waals interactions rather than by ion pairing [2]. Th e physical and chemical property improvements through pharmaceutical co-crystals draw closer the fields of crystal engineering and pharmaceutical sciences [3]. A pharmaceutical co-crystal is simply a co-crystal in which at least one of the molecular components is an API in conjunction with another type of molecule termed a co-crystal former (co-former). Co-crystals can have different properties than the crystals of individual components [4, 5].