شماره ركورد كنفرانس :
4226
عنوان مقاله :
Electrochemical determination of entacapone in the presence of levodopa and carbidopa using a carbon paste electrode modified with a SnO2/CuS nanocomposite.
پديدآورندگان :
Naghian Ebrahim mnajafi@ihu.ac.ir Islamic Azad University , Najafi Mostafa mnajafi@ihu.ac.ir Imam Hossein University
كليدواژه :
Nanocomposite , Entacapone , Levodopa , Carbidopa , Paste electrode 13th Annual Electrochemistry Seminar of Iran Materials and Energy Research Center (MERC) , 22 , 23 Nov , 2017 66 Scheme 1: Chemical structure of ENT. A B Fig 1 : A) Cyclic voltammograms of 0.5 × 10−3 mol L−1 ENT in B–R buffer pH 2 at a scan rate of 50 mV s−1 , carbon past bare (blue peak) , carbon paste SnO2 , CuS nanocomposite (red peak). B) differential pulse voltammetry of carbon paste SnO2 , CuS nanocomposite in B , R buffer (pH 2) contain
عنوان كنفرانس :
سيزدهمين سمينار ملي سالانه الكتروشيمي ايران
چكيده فارسي :
Entacapone (ENT), (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl prop-2-enamide belongs to the class of antiparkinson agents (Scheme 1) [1]. The simultaneous pharmaceutical analysis of multi1component drugs represents a challenge due to a large total number of analytes present in the sample [2]. In this research work, a novel carbon paste modified electrode (CPME) with SnO2/CuS nanocomposite has been developed for electrocatalytic oxidation and determination of the ENT in the presence of levodopa and carbidopa. The electrochemical behavior and determination of ENT at the SnO2/CuS nanocomposite CPME were investigated by cyclic voltammetry and differential pulse voltammetry techniques respectively (Fig 1). The results showed that the sensor had excellent electrocatalytic activity toward determination of ENT and exhibited a wide linear range (2nM-40μM) and a low detection limit (1nM). The proposed electrode displayed excellent repeatability and long-term stability and it was satisfactorily used for determination of ENT in pharmaceutical dosage forms, human plasma and urin with high recovery.
