Mesoporous SiO2 immobilized HClO4 for synthesis of DHPMs and DHPs Heterocycles

Recently, ordered mesoporous silica of SBA-15 has emerged as a catalyst in various organic transformations, especially when low amount of catalyst loading of the catalyst are used [1-3]. Based on our interest in multicomponent reactions [4-6], in this respect, we are used a neat heterogeneous and reusable catalytically ordered mesoporous silica supported perchloric acid (SBA-15/HClO4) mediate for ring-opening reaction of diketene6 in presence of alcohols and aldehydes for preparation of the DHPMs and DHPs heterocycles via urea and ammonium acetate as nuclephile, respectively (Figure 1). The neat approach, simplicity and variability in derivatives of the present four-component procedure makes it an interesting alternative to three-component usual approaches. Fig 1. SBA-15/HClO4 catalyzed synthesis of DHPMs and DHPs.