Designing a multi component reaction for facile synthesis of some novel 2-aryl thiazolidin-4-ones bearing benzimidazole moiety by Nano-NiY Zeolite as an Efficient Nano Catalyst

Development the multicomponent chemical reaction (MCRs) in modern organic chemistry is due to the ability of this method in synthesis of wired natural-product-like molecules. Multicomponent reaction as a powerful tools can couples more than two starting reagent to a single pure product which contains the essential parts of starters. [1-2] 1,3-thiazolidin-4-ones by having sulfur and nitrogen in a five membered ring, are belong to thiazolidones that can be found as a core structure in various synthetic pharmaceutical and agricultural compounds and displaying a broad spectrum of biological activities. They have been employed in the preparation different important drugs such as famotidine, mebendazole and astemizole.[3-4] Nowadays their antifungal, antimicrobial, anticancer, antidiabetic, antiviral and anti HIV activities are reported.[5] On the other hand, biologically and physiologically activity of natural and synthetic molecules that have benzimidazole core have been proved.[6] By considering biological activities of both thiazolidinone and benzimidazole moieties and furthermore, as a part of our ongoing studies on the catalytic synthesis of compounds by benzimidazole nucleus as an important class of fungicides plant, [7] we showed that 2-aminobenzimidazole as an aromatic amine, aromatic aldehydes, and 2-mercaptoacetic acid, under a mild multicomponent reaction that catalyzed by Nano-NiY Zeolite can yield to 2-((1H-benzo[d]imidazol-2-ylamino)(aryl) 1,3-thiazolidin-4-ones 4a-l.